Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pronuclear pattern does not predict morphokinetics behavior in human embryos.

Azita Faramarzi1,2, Mohammad Ali Khalili1, Marjan Omidi1

  • 1a Research and Clinical Center for Infertility , Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences , Yazd , Iran.

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
|October 17, 2017
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Psychiatric nurses' work experiences in non-psychiatric wards in light of their specialized competencies: a qualitative content analysis.

BMC nursing·2026
Same author

Quinic and Ferulic Acid-Loaded Chitosan Nanoparticles Attenuate Experimental Ulcerative Colitis by Modulating the IL-32/IL-33/IL-34 Axis and NF-κB Signaling.

International journal of inflammation·2026
Same author

L-Proline protects human sperm from heat stress-induced oxidative damage.

Amino acids·2026
Same author

Development and content validation of a quantitative informatics framework for hardware assessment in health information systems.

Scientific reports·2026
Same author

IMSI does not improve pregnancy outcomes and live birth rate in severe teratozoospermia patients: a double-blind randomized controlled trial.

Scientific reports·2026
Same author

Concerns on use of PVP in assisted reproduction: a narrative review.

Zygote (Cambridge, England)·2026

Time lapse monitoring (TLM) reveals pronuclei (PN) morphology has limited correlation with embryo development kinetics. However, cleavage rates and embryo arrest significantly correlate with developmental scores in assisted reproduction.

Area of Science:

  • Embryology
  • Reproductive Medicine
  • Biotechnology

Background:

  • Assisted reproduction technologies (ART) rely on accurate embryo assessment.
  • Pronuclei (PN) morphology and embryo morphokinetics are potential indicators of embryo viability.
  • Time-lapse monitoring (TLM) offers continuous observation of early embryonic development.

Purpose of the Study:

  • To investigate the correlation between pronuclei (PN) morphology and the morphokinetic behavior of embryos.
  • To evaluate how PN characteristics (size, contact, nuclear precursor bodies) relate to embryo development.
  • To determine the predictive value of PN morphology and morphokinetics for assisted reproduction outcomes.

Main Methods:

  • Utilized time-lapse monitoring (TLM) to observe and analyze pronuclei (PN) appearance (PNA) and fading (PNF).
Keywords:
Z scoringcleavage patternembryomorphokineticzygote

Related Experiment Videos

  • Assessed PN morphology based on size, contact, number, and position of nuclear precursor bodies (NPBs).
  • Evaluated morphokinetic variables including timing, cleavage patterns, and arrest rates, correlating them with Z-scoring (Z1-Z4).

    • Main Results:

    • No significant relationship was found between most morphokinetic variables (e.g., t2, t3, t4, t5, t6, t7, t8, S1, CC2, S2) and Z-scoring.
    • Uneven blastomeres and reverse cleavage showed no significant correlation with Z-scoring.
    • Significant correlations were observed between direct/arbitrary cleavage rates, arrested embryos, and Z-scores.

    Conclusions:

    • Pronuclei morphology alone has limited predictive power for embryo development when assessed via morphokinetics.
    • Embryo cleavage patterns (direct, arbitrary, arrest) are more significantly correlated with developmental scores than PN morphology.
    • Combining PN morphology with embryo kinetic evaluation is recommended for comprehensive assessment in assisted reproduction programs.