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Effects on Cancellous Bone in the Metaphysis
11 Drug Safety Research and Development, Pfizer Inc., Groton, Connecticut, USA.
Toxicologic Pathology
|October 17, 2017
Abstract:
Cancellous bone has high metabolic activity compared to many other bone compartments and can be affected not only by changes in physeal activity but also by perturbations in homeostasis caused by changes in physiology or on-target pharmacology. Examples of several types of resulting morphologic findings were presented; if known, the pathways causing morphologic changes were discussed.