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Related Experiment Videos

Resveratrol: from diet to topical usage.

Veronica Sanda Chedea1, Simona Ioana Vicaş, Claudia Sticozzi

  • 1Laboratory of Animal Biology, National Research and Development Institute for Biology and Animal Nutrition, Baloteşti (INCDBNA-IBNA), Calea Bucureşti nr. 1, Balotesti, Ilfov 077015, Romania. chedea.veronica@ibna.ro.

Food & Function
|October 17, 2017
PubMed
Summary

Resveratrol (RESV) shows promise for skin health, triggering cellular defense pathways. Further research is needed to optimize topical concentrations for preventing skin aging and damage.

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Area of Science:

  • Biochemistry
  • Dermatology
  • Pharmacology

Background:

  • Resveratrol (3,5,4'-trihydroxy-stilbene; RESV) is a stilbene derivative with recognized biological activities.
  • While initially studied for cardiovascular effects, RESV's benefits extend to cancer chemoprevention and inflammation.
  • RESV's efficacy is linked to modulating cell signaling and gene expression, not solely antioxidant properties.

Purpose of the Study:

  • To review the current understanding of resveratrol's biological activities.
  • To evaluate the potential of topical resveratrol applications in cosmeceuticals.
  • To identify research gaps regarding topical RESV efficacy and optimal concentrations for skin protection.

Main Methods:

  • Literature review of existing studies on resveratrol's effects.

Related Experiment Videos

  • Analysis of in vitro and in vivo research on RESV's mechanisms of action.
  • Evaluation of cosmeceutical industry reports on topical RESV formulations.

    • Main Results:

    • Oral resveratrol absorption is high, but rapid metabolism leads to low blood concentrations.
    • Topical application of RESV shows promising results in protecting skin from environmental damage.
    • Controversy exists regarding optimal concentrations for topical RESV use.

    Conclusions:

    • Resveratrol's benefits are primarily mediated through cellular signaling pathways.
    • Topical RESV holds potential as a cosmeceutical agent for skin protection.
    • More research is required to establish effective topical concentrations and applications for preventing skin aging and damage.