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Xeroderma pigmentosum complementation group D polymorphism toward lung cancer susceptibility survival and response in
Shweta Lawania1, Navneet Singh2, Digamber Behera2
1Department of Biotechnology, Thapar University, Patiala, Punjab 147002, India.
Aim:
The study investigated role of xeroderma pigmentosum complementation group D (XPD) single nucleotide polymorphisms in modulating lung cancer risk and its association with overall survival and clinical outcomes.
Methods:
XPD polymorphisms were detected using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP).
Results:
CC genotype of A751C polymorphism was associated with an increased lung cancer risk (p = 0.01). Classification and Regression Tree (CART) analysis depicted C156A as the major contributing factor. Patients having CC, treated with irinotecan-cisplatin/carboplatin regimen showed a better survival (median survival time = 25.2) whereas a poor survival was for XPD G312A. Similarly, patients treated with pemetrexed and carrying heterozygous genotype of G312A polymorphism had a poor survival (p = 0.01).
Conclusion:
A751C and G312A act as a predictive marker in lung cancer patients treated with platinum chemotherapy. These findings might facilitate therapeutic decisions for individualized therapy in lung cancer patient. [Formula: see text].
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