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Association between growth differentiation factor 15 and left ventricular hypertrophy in hypertensive patients and

Huijuan Kou1, Xin Jin2, Dengfeng Gao1

  • 1a Department of Cardiology , The Second Affiliated Hospital, Xi'an Jiaotong University , Xi'an , P. R. China.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|October 17, 2017
PubMed

Insights

Growth Differentiation Factor 15 (GDF-15) is linked to left ventricular hypertrophy (LVH) in hypertension. Elevated GDF-15 levels independently predict LVH risk in hypertensive patients, suggesting its potential as a key cardiovascular biomarker.

Area of Science:

  • Cardiology
  • Biomarkers
  • Hypertension Research

Background:

  • Cardiovascular diseases (CVDs) pose a significant health burden.
  • Growth Differentiation Factor 15 (GDF-15) is emerging as a potential biomarker for CVDs.
  • Left Ventricular Hypertrophy (LVH) is a common cardiac adaptation in hypertensive patients, increasing CVD risk.

Purpose of the Study:

  • To investigate the association between plasma GDF-15 levels and LVH in hypertensive individuals.
  • To evaluate GDF-15 as an independent biomarker for LVH in hypertension.
  • To explore the relationship between GDF-15, inflammation markers (IL-6, MMP-9), and LVH.

Main Methods:

  • A clinical study involving 302 participants (hypertensive patients with and without LVH, and healthy controls).
  • Echocardiography was used to measure LVH in hypertensive patients.
  • Plasma concentrations of GDF-15, Interleukin-6 (IL-6), and Matrix Metalloproteinase-9 (MMP-9) were determined using ELISA.
  • Statistical analysis included multivariate logistic regression and correlation analysis.

Main Results:

  • Plasma GDF-15, IL-6, and MMP-9 levels were significantly higher in patients with LVH compared to non-LVH patients and healthy controls (p < 0.001).
  • Elevated GDF-15 remained independently associated with LVH after adjusting for confounders.
  • GDF-15 showed a positive correlation with IL-6 and MMP-9, suggesting a link with inflammation.
  • An optimal GDF-15 cut-off point for predicting LVH severity was identified.

Conclusions:

  • GDF-15 is significantly associated with hypertensive LVH.
  • Elevated GDF-15 is an independent predictor of LVH in hypertensive patients.
  • GDF-15 may serve as a valuable biomarker for predicting LVH risk in individuals with hypertension.

Keywords:
Growth differentiation factor 15hypertensioninterleukin 6left ventricular hypertrophymatrix metalloproteinases 9

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