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Updated: Aug 14, 2026
Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
Published on: May 27, 2022
Level of Platelet Distribution Width and Outcome Prediction in Patients with Traumatic Brain Injury
Background:
This study examines the clinical utility of the level of increased platelet distribution width (PDW) as a predictor of outcome in patients with traumatic brain injury.
Methods:
In this retrospective study, 120 patients with traumatic brain injury (TBI) were recruited. Age, gender, PDW, and Glasgow Coma Scale (GCS) scores were measured. These patients were divided into two groups based on their 30-day outcomes. Receiver operating curves (ROCs) were generated to identify predictors of 30-day mortality.
Results:
One hundred twenty patients with traumatic brain injury were enrolled in this study, 89 males (74.2%) and 31 females (25.8%) with a median age of 49.5 (19 - 89) years. The in-hospital mortality rate was 10.8% (n = 13). PDW levels in non-surviving patients were higher than in surviving patients. The higher the PDW, the lower the GSC score. The area under the curve (AUC) for PDW levels with regard to predicting 30-day mortality was 0.88 (95% confidence interval (CI), 0.78 to 0.97; p < 0.001). There was correlation between PDW level and GCS score (r = -0.30, 95% confidence interval (CI), - 0.46 to - 0.13; p < 0.001).
Conclusions:
PDW levels were associated with injury severity and mortality in patients with severe TBI.
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