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Microwave-Facilitated SPOT-Synthesis of Antibacterial Dipeptoids
Anne C Schneider1, Daniel Fritz1, Joseph K Vasquez2
1Institute of Organic Chemistry, Karlsruhe Institute of Technology , Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany.
ACS Combinatorial Science
|October 17, 2017
Abstract:
With microwave irradiation, the submonomer synthesis of dipeptoids on functionalized cellulose can be accelerated with good yields and purity. Optimization provided a library of 96 dipeptoids. From these, 29 compounds were found with an antibacterial activity against MRSA at a concentration of 25 μM. Large nonpolar residues, such as undecylamine and dehydroabiethylamine, are the key components engendering the observed antibacterial activity of these peptoids.