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The role of CIP2A in cancer: A review and update

Saiedeh Razi Soofiyani1, Mohammad Saeid Hejazi2, Behzad Baradaran3

  • 1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Molecular Medicine, Faculty of Advanced Biomedical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|October 17, 2017
PubMed

Insights

Cancerous inhibitor of protein phosphatase 2A (CIP2A) promotes cancer growth by inactivating PP2A, stabilizing c-Myc, and upregulating Akt. Targeting CIP2A offers a potential therapeutic strategy across various human malignancies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a human oncoprotein.
  • CIP2A promotes cancer cell proliferation, anchorage-independent growth, and resistance to apoptosis.
  • CIP2A functions by inactivating protein phosphatase 2A (PP2A).

Purpose of the Study:

  • To discuss the role of CIP2A in human malignancies.
  • To summarize CIP2A expression patterns in various cancers.
  • To explore CIP2A's association with cancer stage, patient prognosis, and its therapeutic targeting potential.

Main Methods:

  • Literature review and data synthesis on CIP2A.
  • Analysis of CIP2A expression in human cancers.
  • Examination of CIP2A's functional mechanisms and localization.
  • Review of potential therapeutic strategies targeting CIP2A.

Main Results:

  • CIP2A inactivates PP2A, leading to decreased Akt phosphorylation and increased c-Myc stabilization.
  • CIP2A expression is observed in most human malignancies.
  • CIP2A's association with cancer stage, prognosis, and localization varies across different cancer types.
  • CIP2A presents a potential therapeutic target in multiple cancers.

Conclusions:

  • CIP2A is a significant oncoprotein implicated in cancer progression through PP2A/Akt/c-Myc pathway.
  • Understanding CIP2A expression and its correlation with clinical outcomes is crucial.
  • Targeting CIP2A holds promise for novel cancer therapies.
Keywords:
CIP2ACancerOncoproteinPP2Ac-Myc

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