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[Somatostatin deficiency, hyperinsulinism and thrombocyte aggregation in psoriasis]
1Hautklinik am Klinikum Nürnberg.
Zeitschrift Fur Hautkrankheiten
|July 15, 1988
Summary
Yohimbine therapy normalized blood levels in chronic psoriasis patients. This treatment addressed decreased somatostatin, hyperinsulinemia, and low platelet counts common in psoriasis.
Area of Science:
- Dermatology
- Endocrinology
- Hematology
Background:
- Chronic psoriasis is associated with specific blood abnormalities.
- These include decreased somatostatin, hyperinsulinemia, and thrombocytopenia (low platelet counts).
- Yohimbine is an alpha 2-adrenoceptor antagonist with known effects on insulin and platelets.
Purpose of the Study:
- To investigate the therapeutic efficacy of yohimbine and colchicine in chronic psoriasis.
- To determine if yohimbine can correct associated hematological and endocrine abnormalities.
Main Methods:
- A cohort of 59 patients with chronic psoriasis was studied.
- Therapeutic effects of yohimbine and colchicine were assessed.
- Blood levels of somatostatin, insulin, and platelets were monitored.
Main Results:
- 85% of patients exhibited decreased somatostatin levels.
- 88% of patients presented with hyperinsulinemia.
- Low platelet counts were observed in the patient group.
- Successful yohimbine therapy led to the normalization of these pathological blood markers.
Conclusions:
- Yohimbine demonstrates therapeutic potential for chronic psoriasis.
- The drug effectively reverses associated hyperinsulinemia and thrombocytopenia.
- Yohimbine may offer a novel treatment strategy for psoriasis by targeting underlying metabolic and hematological dysfunctions.