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Related Experiment Videos

iSyTE 2.0: a database for expression-based gene discovery in the eye.

Atul Kakrana1, Andrian Yang2,3, Deepti Anand4

  • 1Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19711, USA.

Nucleic Acids Research
|October 17, 2017
PubMed
Summary

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The enhanced iSyTE 2.0 database offers comprehensive lens gene expression data for improved eye gene discovery. This tool aids researchers in identifying genes linked to lens development and diseases.

Area of Science:

  • Genomics
  • Bioinformatics
  • Ophthalmology

Background:

  • Previous iSyTE version limited by few mouse lens stages and visualization options.
  • Need for a comprehensive resource for eye gene discovery.

Purpose of the Study:

  • To present iSyTE 2.0, an enhanced database for lens gene discovery.
  • To provide a user-friendly portal for visualizing and analyzing lens expression data.

Main Methods:

  • Integrated all public lens microarray datasets (Affymetrix, Illumina) across various mouse developmental stages.
  • Developed a new web interface for data access, visualization, and analysis.
  • Included data from wild-type and gene-perturbation mouse models.

Main Results:

Related Experiment Videos

  • iSyTE 2.0 offers comprehensive genome-level lens expression data.
  • New interface allows easy searching, visualization, and downstream analysis.
  • Tutorial examples demonstrate utility for known lens genes.

Conclusions:

  • iSyTE 2.0 facilitates candidate gene prioritization for eye development and disease research.
  • The database supports transcriptomics, next-generation sequencing, linkage analysis, and GWAS.
  • Enhanced iSyTE 2.0 is a valuable resource for ocular gene discovery.