Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

DelPhiForce web server: electrostatic forces and energy calculations and visualization.

Lin Li1, Zhe Jia1, Yunhui Peng1

  • 1Department of Physics, Clemson University, Clemson, SC 29631, USA.

Bioinformatics (Oxford, England)
|October 17, 2017
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From extracellular entry to intracellular release: A water-assisted transport cycle for creatine in SLC6A8.

Protein science : a publication of the Protein Society·2026
Same author

Functional and Structural Characterization of Pathogenicity of Human Arginine-Histidine Variants.

Journal of computational biophysics and chemistry·2026
Same author

Accurate and Scalable Continuum Electrostatics for Large Biomolecular Systems: The <i>pyDelPhi</i> Poisson-Boltzmann Framework.

Journal of chemical information and modeling·2025
Same author

On generalizing the induced surface charge method to heterogeneous Poisson-Boltzmann models for electrostatic free energy calculation.

Journal of computational physics·2025
Same author

PKAD-R: curated, redesigned and expanded database of experimental pKa values in proteins.

Journal of computational biophysics and chemistry·2025
Same author

Gatifloxacin detection in the nanoscale: a review exploring current biosensing technologies and future opportunities.

RSC advances·2025

Accurate electrostatic force calculations are vital for understanding biological processes. The new DelPhiForce web server visualizes these forces at the molecular level, aiding in the study of various biomolecular interactions.

Area of Science:

  • Biophysics
  • Computational Biology
  • Molecular Modeling

Background:

  • Electrostatic forces are fundamental to molecular interactions in biological systems.
  • Accurate calculation of these forces is essential for elucidating biological mechanisms.
  • Existing methods may lack comprehensive visualization capabilities for electrostatic forces.

Purpose of the Study:

  • To develop and present the DelPhiForce web server for calculating and visualizing electrostatic forces.
  • To provide a tool for analyzing electrostatic interactions at the atomic and molecular levels.
  • To demonstrate the server's utility across diverse biological interaction types.

Main Methods:

  • Development of the DelPhiForce web server.
  • Implementation of electrostatic force calculations at the molecular level.

Related Experiment Videos

  • Integration with visualization software (VMD) for output interpretation.

    • Main Results:

    • The DelPhiForce web server enables modeling of electrostatic forces on various biological entities (atoms, residues, domains, molecules).
    • The server generates visualizable output compatible with VMD.
    • Successful application demonstrated for protein-cofactor, domain-domain, protein-protein, protein-DNA, and protein-RNA interactions.

    Conclusions:

    • The DelPhiForce web server is a valuable tool for calculating and visualizing electrostatic forces.
    • Accurate electrostatic force analysis is crucial for understanding biological mechanisms.
    • The server facilitates research on a wide range of biomolecular interactions.