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No effect on the short-term of a decrease in blood viscosity on insulin resistance.

Agostino Gnasso1, Michele Cacia1, Claudio Cortese2

  • 1Department of Experimental and Clinical Medicine, Magna Græcia University of Catanzaro, Catanzaro, Italy.

Clinical Hemorheology and Microcirculation
|October 18, 2017
PubMed
Summary

Reducing blood viscosity through blood donation in healthy males did not alter insulin resistance. Further studies are needed to explore this effect in individuals with existing insulin resistance.

Keywords:
Insulin-resistanceblood viscosityclampiHOMA2

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Area of Science:

  • Physiology
  • Metabolic Health
  • Hematology

Background:

  • Blood viscosity (BV) may impact glucose delivery and insulin resistance, but the relationship remains unclear.
  • Understanding BV's role is crucial for insights into diabetes mellitus.
  • Previous research has not definitively established the link between BV and insulin resistance.

Purpose of the Study:

  • To investigate the impact of acutely reducing blood viscosity on insulin resistance.
  • To assess changes in insulin sensitivity following a reduction in blood viscosity.
  • To evaluate the effects in healthy male subjects.

Main Methods:

  • Studied 15 healthy males before and after blood donation (48 hours).
  • Measured blood and plasma viscosity using a cone-plate viscometer at 37°C.
  • Assessed insulin resistance via euglycemic/hyperinsulinemic clamp and iHOMA2 Index.

Main Results:

  • Blood viscosity significantly decreased post-donation (p < 0.05).
  • Insulin resistance remained unchanged as measured by both clamp and iHOMA2 Index (p = NS).
  • Blood pressure and lipid profiles were unaffected by blood donation.

Conclusions:

  • Acute reduction in blood viscosity does not affect insulin resistance in healthy males.
  • Current findings suggest BV reduction alone may not be sufficient to alter insulin sensitivity.
  • Further research is warranted to examine BV reduction's effects in insulin-resistant populations.