Effects on urine profiles of diatrizoate in hydrated and dehydrated rats. A double cross-over study

Effects of intravenous diatrizoate on urine profiles in hydrated and dehydrated rats were compared. In 12 normal rats albumin, glucose, sodium, and the enzymes LDH and GGT were followed twice over 3 hours. The 6 rats being dehydrated at the first examination were hydrated 28 days later and vice versa. At both examinations diatrizoate affected all profile components significantly during the first two hours and caused a 3 per cent weight loss in both groups. Only one significant difference between the hydrated and dehydrated rats was found: The excretion of the brush border enzyme GGT was 1.5 times higher in the dehydrated than in the hydrated rats in both series. Thus, the effect of diatrizoate on the tubular brush border seems to depend on the state of hydration in normal rats.