Related Experiment Video
Updated: Feb 20, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
Published on: August 9, 2022
Stabilization of alpha-lipoic acid by complex formation with octenylsuccinylated high amylose starch
Yi-Xuan Li1, Eun Young Park2, Seung-Taik Lim1
1Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 136-701, South Korea.
Abstract:
The thermal and oxidative stability of alpha-lipoic acid (ALA) in aqueous dispersions containing beta-cyclodextrin (CD), native high amylose (HA) and octenylsuccinylated high amylose (OS) starches (0.1% ALA and 1.0% CD or starch solids) were compared. Both native and modified starches increased the stability of ALA against thermal degradation and oxidation at higher degrees than CD. The OS was more effective in stabilizing ALA than HA. The ALA loss in the dispersions occurred mainly in the supernatant, suggesting that the complex formation of ALA with amylose played a key role in the stabilization. In an in vitro digestion test, the release of ALA from OS dispersion was less than that of HA dispersion, indicating that ALA complexed with OS amylose was most stable against digestion. The octenylsuccinylated high amylose starch was an effective protecting agent for ALA in aqueous media, as well as a delivery carrier for ALA in digestive tract.
Related Concept Videos
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Phase II Reactions: Sulfation and Conjugation with α-Amino Acids
Complexation Equilibria: Factors Influencing Stability of Complexes

