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Cationic nanoemulsions as nucleic acids delivery systems.

Helder Ferreira Teixeira1, Fernanda Bruxel2, Michelle Fraga3

  • 1Programa de Pós-Graduação em Ciências Farmacêuticas da Universidade Federal do Rio Grande do Sul (UFRGS), Faculdade de Farmácia, Av. Ipiranga 2752, 90610-000, Porto Alegre, RS, Brazil.

International Journal of Pharmaceutics
|October 18, 2017
PubMed

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Summary

Cationic nanoemulsions offer a promising nonviral gene delivery strategy, overcoming viral vector limitations. These nanotechnology-based systems demonstrate efficient nucleic acid protection and delivery for gene therapy applications.

Area of Science:

  • Biotechnology
  • Nanotechnology
  • Gene Therapy

Background:

  • Gene therapy has advanced, leading to approved gene medicines.
  • Viral vectors face safety and immune response limitations.
  • Nonviral vectors, particularly nanotechnology-based systems, are explored as alternatives.

Purpose of the Study:

  • To review cationic nanoemulsions for gene therapy.
  • To provide an overview of their composition and properties.
  • To assess their efficacy in biological responses.

Main Methods:

  • Review of literature on cationic nanoemulsions for gene therapy.
  • Analysis of their composition and physicochemical properties.
  • Evaluation of in vitro and in vivo biological responses.
Keywords:
Cationic lipidsCationic nanoemulsionsGene therapyNanotechnologyNonviral vectorsNucleic acid delivery

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Main Results:

  • Cationic nanoemulsions are effective nonviral gene delivery systems.
  • They offer protection and efficient delivery of nucleic acids.
  • Demonstrated efficacy in both in vitro and in vivo studies.

Conclusions:

  • Cationic nanoemulsions are a promising approach for gene therapy.
  • They represent an advancement over traditional viral vectors.
  • Further research into these systems holds therapeutic potential.