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Related Experiment Videos

Revealing the genomic differences between two subgroups in Lactobacillus gasseri.

Ipputa Tada1, Yasuhiro Tanizawa2, Akihito Endo3

  • 1Department of Genetics, School of Life Science, The Graduate University of Advanced Studies, Mishima, Shizuoka 411-8540, Japan.

Bioscience of Microbiota, Food and Health
|October 18, 2017
PubMed
Summary

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Genomic analysis of Lactobacillus gasseri revealed two distinct groups. These findings support the demarcation of a new probiotic group within this widely used species.

Area of Science:

  • Microbiology
  • Genomics
  • Probiotics

Background:

  • Lactobacillus gasseri is a common inhabitant of the human gut and a popular probiotic in fermented foods.
  • Understanding its genetic diversity is crucial for optimizing its use and safety.

Purpose of the Study:

  • To compare the gene content of 75 Lactobacillus gasseri genomes.
  • To identify distinct intraspecific groups within L. gasseri based on genomic data.
  • To provide evidence for demarcating a new probiotic group.

Main Methods:

  • Whole-genome sequencing and comparative genomics were employed.
  • Average Nucleotide Identity (ANI) analysis was used to determine genomic relatedness.
  • Group-specific genes were identified and annotated.
Keywords:
Lactobacillus gassericomparative genomicsgassericin Tquorum sensing

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Main Results:

  • Two distinct intraspecific groups of L. gasseri were identified with an ANI threshold of 94%.
  • Group I (48 strains) contained unique genes, including the gassericin T cluster and N-acyl homoserine lactone lactonase.
  • Group II (27 strains) harbored plasmid- or phage-related genes.

Conclusions:

  • Genomic disparities between the two groups offer a basis for classifying a new probiotic group within L. gasseri.
  • The identified genetic differences may influence the functional properties and applications of L. gasseri strains.
  • Further research into these specific gene clusters could enhance probiotic development.