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Published on: October 26, 2017
MicroRNAs as Biomarkers in Thyroid Carcinoma
Marilena Celano1, Francesca Rosignolo2, Valentina Maggisano1
1Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy.
International Journal of Genomics
|October 18, 2017
Summary
MicroRNA expression in thyroid tumors offers new hope for developing sensitive biomarkers. These novel microRNA biomarkers could significantly improve the early diagnosis and management of thyroid cancer.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Current thyroid cancer biomarkers (thyroglobulin, calcitonin) have limitations in sensitivity and specificity.
- Optimal patient management necessitates improved diagnostic and prognostic tools.
- MicroRNA research presents a promising avenue for novel biomarker discovery.
Purpose of the Study:
- To review methods for detecting and quantifying microRNAs in thyroid tumor biospecimens.
- To explore the potential of microRNA-based biomarkers for thyroid cancer diagnosis.
- To evaluate microRNAs for prognostic assessment in thyroid cancer patients.
Main Methods:
- Review of current scientific literature on microRNA detection techniques.
- Analysis of microRNA quantification methods in clinical samples.
- Examination of studies linking microRNA expression to thyroid cancer characteristics.
Main Results:
- MicroRNA expression profiling reveals distinct patterns in thyroid tumors.
- Various techniques exist for microRNA detection and quantification, each with advantages.
- Emerging evidence supports microRNAs as potential diagnostic and prognostic markers.
Conclusions:
- MicroRNA analysis holds significant potential for advancing thyroid cancer diagnostics.
- Development of microRNA-based assays could overcome limitations of current biomarkers.
- Further research is needed to validate microRNAs for routine clinical application in thyroid cancer management.
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