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Updated: Sep 26, 2026
Establishment of an Embryo Implantation Model In Vitro
Published on: June 21, 2024
[Effect of oxygen concentration on outcome of in-vitro fertilization-embryo transfer]
Enshu Li1, Xiaoqun Ye1, Li Fang1
1Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Key Laboratory of Reproductive Genetics, Ministry of Education, Hangzhou 310006, China.
Objective:
To investigate the effect of low and high oxygen concentration on embryo development, pregnancy outcome and birth defects of in vitro fertilization-embryo transfer (IVF-ET).
Methods:
According to the oxygen concentration of in vitro culture environment, the IVF-ET performed in the Women's Hospital, Zhejiang University School of Medicine during 2013 and 2015 were divided into low oxygen concentration group (n=2036, 5% O2) and high oxygen concentration group (n=4617, 20% O2). The rate of fertilization, good quality embryo, clinical pregnancy, ectopic pregnancy, abortion and birth defect were compared between two groups.
Results:
The good quality embryo rate was significantly higher in the low oxygen concentration group (P<0.05). However, no significant differences were found between two groups in the rate of fertilization, clinical pregnancy, ectopic pregnancy, abortion and birth defect (all P>0.05).
Conclusions:
Low oxygen environment may improve the potential of embryonic development, but its impact on pregnancy outcome and birth defect is not significant.
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