Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Liquid-Solid Dual-Gate Organic Transistors with Tunable Threshold Voltage for Cell Sensing.

Yu Zhang, Jun Li1, Rui Li

  • 1Department of Chemistry and Centre for Plastic Electronics, Imperial College , London SW7 2AZ, U.K.

ACS Applied Materials & Interfaces
|October 18, 2017
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interfacial Potential Compensation for HOMO Alignment in Ternary Organic Solar Cells.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Deletion of <i>steD</i> gene and <i>yejAE</i> operons in LPS-deficient <i>Salmonella</i> elicits strong t cell immunity and complete protection against homologous serotypes.

Frontiers in microbiology·2026
Same author

Intimate Interaction Between Nucleic Acid and Conjugated Polymers in Organic Electrochemical Transistors Enables Ultrasensitive Biomarker Detection.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

<i>Salmonella</i>-derived OMVs as a vaccine platform for <i>Riemerella anatipestifer</i> outer membrane proteins to prevent infection in ducks.

Applied and environmental microbiology·2026
Same author

Linker-Engineered Dimeric Acceptors Afford Efficient Organic Photocatalytic Hydrogen Evolution via Tailored Nanomorphology for Long-Lived Charge Accumulation.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Engineered OMVs of Salmonella displaying PlpE antigen provide effective protection against Pasteurella multocida infection in mice.

Vaccine·2026

A novel dual-gate organic transistor design allows for precise voltage tuning, significantly improving cell sensing capabilities without causing cell damage. This enhances organic bioelectronics performance and material options.

Area of Science:

  • Organic electronics
  • Bioelectronics
  • Biophysics

Background:

  • Liquid electrolyte-gated transistors are used for cell sensing but limited by low operating voltages.
  • High gate voltages can damage cell membranes, restricting transistor performance.
  • Current limitations hinder optimal transconductance and sensitivity in cell-based biosensors.

Purpose of the Study:

  • To develop a new organic transistor structure for improved cell sensing.
  • To overcome the voltage limitations of existing liquid-gated transistors.
  • To enhance the sensitivity and performance of organic bioelectronic devices.

Main Methods:

  • Utilized a solid-liquid dual-gate organic transistor architecture.
  • Employed a metal-oxide dielectric to separate the control gate from the sensing channel.
Keywords:
cell sensingdual-gateelectrolyte-gated organic field effect transistororganic electrochemical transistorthreshold voltage tuning

Related Experiment Videos

  • Tuned the threshold voltage of the liquid-gated conduction channel.

    • Main Results:

    • Demonstrated linear tuning of the sensing channel's threshold voltage over a 0.4 V window.
    • Achieved significantly improved sensor response to human mesenchymal stem cell detachment.
    • Showcased the dual-gate structure's ability to optimize sensing bias.

    Conclusions:

    • The dual-gate design effectively tunes the optimal sensing bias for organic transistors.
    • This approach enhances device performance and broadens material choices for cell-based bioelectronics.
    • The technology offers a promising advancement for sensitive and reliable cell monitoring.