Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Visuospatial Functioning in the Primary Progressive Aphasias.

Christa L Watson1, Katherine Possin2, I Elaine Allen3

  • 11Department of Neurology,Dyslexia Center,University of California,San Francisco,California.

Journal of the International Neuropsychological Society : JINS
|October 18, 2017
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discriminating nonfluent/agrammatic and logopenic PPA variants with automatically extracted morphosyntactic measures from connected speech.

Cortex; a journal devoted to the study of the nervous system and behavior·2024
Same author

Feasibility and acceptability of remote smartphone cognitive testing in frontotemporal dementia research.

Alzheimer's & dementia (Amsterdam, Netherlands)·2023
Same author

Correction: Cortical microstructure in primary progressive aphasia: a multicenter study.

Alzheimer's research & therapy·2023
Same author

Automated Detection of Speech Timing Alterations in Autopsy-Confirmed Nonfluent/Agrammatic Variant Primary Progressive Aphasia.

Neurology·2022
Same author

Auditory Verb Generation Performance Patterns Dissociate Variants of Primary Progressive Aphasia.

Frontiers in psychology·2022
Same author

Right temporal degeneration and socioemotional semantics: semantic behavioural variant frontotemporal dementia.

Brain : a journal of neurology·2022
This summary is machine-generated.

Primary progressive aphasia (PPA) variants show distinct visuospatial deficits. Logopenic PPA has the most visuospatial and visual memory impairments, aiding differential diagnosis.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neurology

Background:

  • Primary progressive aphasia (PPA) is a neurodegenerative disorder affecting language.
  • PPA presents with three main variants: logopenic, nonfluent, and semantic.
  • Understanding non-linguistic deficits, such as visuospatial cognition, is crucial for diagnosis and management.

Purpose of the Study:

  • To investigate differential visuospatial cognitive profiles across the three main PPA variants.
  • To determine if visuospatial deficits can aid in distinguishing between PPA variants.
  • To explore the longitudinal changes in visuospatial functioning within PPA variants.

Main Methods:

  • A cohort of 156 PPA patients and controls were assessed using a comprehensive visuospatial cognitive test battery.
Keywords:
Alzheimer diseaseFrontotemporal dementiaLanguageMental processesNeuropsychological testsSpatial processing

Related Experiment Videos

  • Group comparisons were made on an overall visuospatial factor, composite scores (construction, recall, executive function), and individual tests.
  • Statistical analyses included cross-sectional and longitudinal comparisons, adjusted for disease severity, age, and education.

    • Main Results:

    • The logopenic PPA variant exhibited the most significant deficits across visuospatial and visual memory measures.
    • The nonfluent variant showed broad visuospatial difficulties, except for preserved delayed recall.
    • The semantic variant's primary deficit was in delayed visual recall, with preserved figure copying over time.

    Conclusions:

    • Visuospatial performance profiles differ significantly among PPA variants, offering diagnostic value.
    • Delayed visual recall is a key differentiator between logopenic and nonfluent PPA.
    • The findings suggest shared mechanisms underlying linguistic and non-linguistic deficits in PPA and highlight the importance of longitudinal visuospatial assessment.