Mini Review - Analysis of Artemether and Dihydroartemisinin by high performance high liquid chromatography in
Shabana Ali1, Nusrat Jafery2, Kulsoom Farhat1
1Department of Pharmacology and Therapeutics, Army Medical College, National University of Sciences and Technology, Islamabad, Pakistan.
Abstract:
Artemether-Lumefantrine is the most widely recommended antimalarial combination used to treat millions of patients suffering from malaria. Artemether undergoes rapid metabolism and gets converted to its active metabolite dihydroartemisisn. Drug analysis is a vital aspect to evaluate drugs in research. There are a number of methods available for the determination of artemether in biological fluids. These methods include HPLC based UV detection, GS-MS, HPLC-ECD and HPLC-MS/MS. This article reviews different methods for the determination of artemether in the biological fluids. Among the available methods HPLC-MS/MS proves to be the most accurate and reliable one for analysis. This has the advantage of improved sensitivity and selectivity with smaller sample volume.
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