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Transglutaminase in cell proliferation and transformation
S Metafora1, G Peluso, G Ravagnan
1CNR Institute of Protein Biochemistry and Enzymology, Naples, Italy.
Medical Oncology and Tumor Pharmacotherapy
|January 1, 1988
Abstract:
Transglutaminase (TGase) activity was reduced in intact mitogen-stimulated human peripheral blood lymphocytes (PBL) when compared to intact resting PBL. Moreover, a treatment of the same quiescent immunocompetent cells with purified liver TGase and Ca2+ completely suppressed the mitogen-induced blast transformation. A decrease in TGase activity in neoplastically transformed seminal vesicle epithelial cells with respect to their normal parent counterpart was also observed. Our data support the notion of a possible implication of TGase in cell proliferation and transformation.