[Corrigendum] Farnesoid X receptor deletion improves cardiac function, structure and remodeling following myocardial

Jianshu Gao1, Xiaoqiang Liu2, Bingjian Wang3

  • 1Department of Cardiology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, P.R. China.

Insights

A correction clarifies the specific antibody used for farnesoid-X receptor (FXR) western blot analysis in a study on myocardial ischemia/reperfusion injury. The findings remain valid despite the methodological error.

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Biochemistry

Background:

  • The study investigated the role of farnesoid-X receptor (FXR) in myocardial ischemia/reperfusion injury.
  • Accurate methodological details are crucial for reproducibility and scientific integrity.

Purpose of the Study:

  • To correct a methodological error regarding the antibody used for western blot analysis of FXR.
  • To confirm that the scientific conclusions of the original study remain unaffected by this correction.

Main Methods:

  • Western blot analysis was performed to detect FXR.
  • A specific antibody against the C-terminus of FXR (Santa Cruz Biotechnology, sc-1204) was used.
  • The correction clarifies the source and specifications of the antibody used.

Main Results:

  • The original study incorrectly cited an antibody from Cell Signalling Technology.
  • The correct antibody used was from Santa Cruz Biotechnology, raised against the C-terminus of FXR.
  • The error in antibody referencing did not alter the study's main conclusions.

Conclusions:

  • The scientific findings regarding FXR's role in myocardial ischemia/reperfusion injury are robust.
  • This correction ensures accurate reporting of experimental methods.
  • Transparency in scientific reporting is essential for the research community.

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