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Highly Efficient Red-Emitting Carbon Dots with Gram-Scale Yield for Bioimaging.

Hui Ding1, Ji-Shi Wei2, Ning Zhong1

  • 1College of Chemical Engineering, China University of Mining and Technology , Xuzhou 221008, Jiangsu, P. R. China.

Langmuir : the ACS Journal of Surfaces and Colloids
|October 18, 2017
PubMed
Summary

Researchers developed gram-scale red-emitting carbon dots (R-CDs) with high quantum yield for bioimaging. These biocompatible nanomaterials offer a promising solution for advanced in vitro and in vivo imaging applications.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Carbon dots (CDs) are versatile photoluminescent nanomaterials with desirable properties like biocompatibility and eco-friendliness.
  • Developing efficient red-emitting carbon dots (R-CDs) on a large scale remains a significant challenge, limiting their bioimaging applications.

Purpose of the Study:

  • To synthesize gram-scale R-CDs with high quantum yield (QY) for enhanced bioimaging.
  • To investigate the properties and potential applications of these novel R-CDs.

Main Methods:

  • Gram-scale synthesis of R-CDs via thermal treatment of citric acid and ethylenediamine in formamide.
  • Characterization of R-CDs' size, nitrogen content, photoluminescence (PL) properties, and stability.
  • Evaluation of R-CDs' cytotoxicity and performance as fluorescence probes in vitro and in vivo.

Main Results:

  • Successful synthesis of R-CDs on a gram scale with a high QY of 53%.
  • R-CDs exhibit excitation-independent red emission at 627 nm, average size of 4.1 nm, and ~30% nitrogen content.
  • Strong red fluorescence attributed to nitrogen- and oxygen-related surface states and nitrogen-derived core structures.
  • Demonstrated good photostability, low cytotoxicity, and effective performance in bioimaging.

Conclusions:

  • The developed R-CDs are highly efficient, scalable, and suitable for bioimaging.
  • These R-CDs represent a significant advancement in red fluorescence probes for both in vitro and in vivo applications.