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Maternal and cord blood cyclophilin A in severe preeclampsia and normal pregnancy and its correlation with vitamin D
Noroyono Wibowo1, Riyan Hari Kurniawan2, Rima Irwinda1
1a Fetomaternal Division, Department of Obstetrics and Gynecology , Faculty of Medicine University of Indonesia - Cipto Mangunkusumo Hospital , Jakarta , Indonesia.
Objective:
To investigate maternal and cord blood cyclophilin A level in severe preeclampsia compared with normal pregnancy and its correlation with vitamin D and zinc level.
Methods:
We conducted a cross-sectional observational study of pregnant women who gave birth in Cipto Mangunkusumo Hospital between January and April 2014.
Results:
Thirty-nine subjects were included. Subjects with severe preeclampsia have higher serum cyclophilin A levels compared with normotensive pregnancy (1299.60 vs. 1039.50; p 0.017). Maternal cyclophilin A, vitamin D, and zinc correlation were not statistically significant (p 0.189 & p 0.853).
Conclusion:
Cyclophilin A levels in severe preeclampsia is higher compared to normal pregnancy. There is no correlation between cyclophilin A, zinc, and vitamin D.
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