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TESTOSTERONE SUPPLEMENTATION AND RETINAL VASCULAR DISEASE.

Vaidehi S Dedania1, David N Zacks1, Wei Pan2

  • 1Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan.

Retina (Philadelphia, Pa.)
|October 18, 2017
PubMed
Summary

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Testosterone supplementation is linked to a higher risk of retinal artery occlusion (RAO), a serious eye condition. However, this study found no significant association between testosterone use and retinal vein occlusion (RVO).

Area of Science:

  • Ophthalmology
  • Endocrinology
  • Pharmacology

Background:

  • Testosterone supplementation is increasingly used for various conditions in men.
  • Potential adverse effects of testosterone therapy on vascular health require investigation.
  • Retinal vascular occlusive events, including retinal artery occlusion (RAO) and retinal vein occlusion (RVO), are significant causes of vision loss.

Purpose of the Study:

  • To investigate the association between testosterone supplementation and the risk of developing retinal artery occlusion (RAO) or retinal vein occlusion (RVO).

Main Methods:

  • A retrospective matched cohort study utilized a large U.S. insurance database from 2000 to 2013.
  • 35,784 male patients initiating testosterone therapy were compared to 178,860 matched controls.

Related Experiment Videos

  • Cox proportional hazard regression analysis was performed, controlling for age, race, diabetes, and hypertension.

    • Main Results:

    • Testosterone users had a significantly increased hazard of RAO (HR: 1.43, 95% CI: 1.12-1.81, P=0.004).
    • No significant association was found between testosterone supplementation and the hazard of RVO (HR: 1.03, 95% CI: 0.74-1.42, P=0.86).
    • The incidence of both RAO and RVO was low in the study population.

    Conclusions:

    • Testosterone supplementation therapy is associated with an increased hazard of retinal artery occlusion (RAO).
    • The study did not find a significant association between testosterone supplementation and retinal vein occlusion (RVO).
    • While the incidence is low, the increased risk of RAO warrants consideration in patients undergoing testosterone therapy.