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Life expectancy in Down syndrome adults.

P A Baird1, A D Sadovnick

  • 1Department of Medical Genetics, University of British Columbia, Canada.

Lancet (London, England)
|December 10, 1988
PubMed
Summary

Life expectancy for individuals with Down syndrome has improved but remains significantly lower than the general population. About 44% of those with Down syndrome survive to 60, compared to 86% of the general population.

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Area of Science:

  • Medical research
  • Genetics
  • Public Health

Background:

  • Down syndrome is a genetic disorder associated with intellectual disability and developmental delays.
  • Previous estimates indicated lower life expectancy for individuals with Down syndrome.

Purpose of the Study:

  • To calculate and analyze the life expectancy of individuals with Down syndrome.
  • To compare survival rates of Down syndrome individuals with the general population.

Main Methods:

  • Analysis of data from 1610 liveborn individuals with Down syndrome.
  • Data collected from over 1,500,000 consecutive live births in British Columbia.
  • Study period: 1908 to 1981.

Main Results:

  • Predicted survival to 68 years is better than previous estimates.
  • Approximately 44.4% of liveborn Down syndrome individuals survive to 60 years.
  • Only 13.6% of liveborn Down syndrome individuals survive to 68 years, compared to 78.4% in the general population.

Conclusions:

  • Life expectancy for individuals with Down syndrome has improved.
  • Survival rates, while better, are still substantially lower than the general population.
  • Further research and support are needed to improve long-term outcomes for individuals with Down syndrome.

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