Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mapping Selection within Drosophila melanogaster Embryo's Anatomy.

Irepan Salvador-Martínez1, Marta Coronado-Zamora2, David Castellano3

  • 1Evo-devo Helsinki Community, Centre of Excellence in Experimental and Computational Developmental Biology, Institute of Biotechnology, University of Helsinki, Helsinki, Finland.

Molecular Biology and Evolution
|October 18, 2017
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Scalable hypothalamic neuron differentiation from human pluripotent stem cells suitable for modeling metabolic disorders.

Stem cell reports·2026
Same author

Immunoediting restricts clonal neoantigens in primary, treatment-naive human tumors.

Immunity·2026
Same author

PSMC-FAC: Automated Optimization of False-Negative Rate Corrections for Low-Coverage PSMC-Based Demographic Inference.

Biology·2026
Same author

Generation and characterization of POMC-tdTomato reporter human pluripotent stem cell lines.

Stem cell research·2026
Same author

Role of CEBPa in trophectoderm competence installment.

Science advances·2025
Same author

Transcription start sites experience a high influx of heritable variants fueled by early development.

Nature communications·2025

This study maps adaptation in Drosophila melanogaster embryos by analyzing gene expression and genomic variation. It reveals selective constraint in digestive and ectodermal tissues, but high adaptive rates in the germline and specific mesodermal structures.

Area of Science:

  • Evolutionary biology
  • Developmental biology
  • Genomics

Background:

  • Understanding adaptation requires integrating genomic variation with developmental processes.
  • Drosophila melanogaster provides a powerful model for studying embryonic development and evolution.

Purpose of the Study:

  • To create an adaptation map of the entire Drosophila melanogaster embryo.
  • To investigate the relationship between gene function, expression patterns, and evolutionary adaptation across anatomical structures.

Main Methods:

  • Analyzed spatial gene expression data for 5,969 genes from the BDGP database.
  • Assessed gene polymorphism and divergence using data from the Drosophila Genetic Reference Panel (DGRP).
  • Estimated the proportion of adaptive, neutral, and deleterious substitutions using the distribution of fitness effects-alpha method.
Keywords:
DFE-alphaDrosophilaadaptationcodon usageembryo anatomyevo-devoexpression biasgene expressionnatural selectionphylogenetic ageselective constraint

Related Experiment Videos

Main Results:

  • Digestive system and ectoderm-derived structures exhibit significant selective constraint.
  • Germline and certain mesoderm-derived structures show elevated rates of adaptive substitution.
  • Genes with restricted expression patterns display higher expression bias, younger phylogenetic ages, and less constraint.

Conclusions:

  • Different embryonic structures experience distinct modes and rates of selection.
  • Gene expression patterns and developmental roles are linked to evolutionary adaptation.
  • The study provides a comprehensive map of adaptation across the Drosophila embryo.