Related Experiment Videos
Intussusception Rate Among Under-Five-Children Before Introduction of Rotavirus Vaccine in North India
Madhu Gupta1, Ravi Kanojia2, Ritesh Singha1
1Department of Community Medicine, School of Public Health, PGIMER, Sector 12, Chandigarh 160012, India.
Insights
Establishing intussusception surveillance in North India provided crucial baseline data on hospital admissions and incidence rates prior to rotavirus vaccine introduction. This information is vital for future public health impact assessments.
Area of Science:
- Pediatrics
- Public Health
- Epidemiology
Background:
- Baseline data on intussusception are essential for evaluating the impact of rotavirus vaccine introduction.
- Understanding pre-vaccine intussusception rates is critical for public health policy and vaccine efficacy studies.
Purpose of the Study:
- To establish a surveillance system for intussusception in North India.
- To estimate the hospital admission and incidence rates of intussusception in children under five years of age before rotavirus vaccine introduction.
Main Methods:
- A hospital-based, bidirectional surveillance system was implemented in Chandigarh, India.
- Data collection included retrospective (2009-2012) and prospective (2013-2015) phases, enrolling children under five years with intussusception.
- Brighton's classification criteria were used to diagnose intussusception cases.
Main Results:
- A total of 277 intussusception cases were reported, with 72% occurring in infants and 69.7% in males.
- The median age at diagnosis was 10 months.
- Estimated incidence rates were 20 per 100,000 infants and 5 per 100,000 children under five years annually.
Conclusions:
- The established surveillance system successfully provided essential background data on intussusception.
- These findings offer critical incidence and hospital admission rates preceding rotavirus vaccine implementation in North India.
Background:
Baseline data on intussusception are needed to compare the intussusception rates following introduction of rotavirus vaccine.
Methods:
A hospital-based bidirectional surveillance (retrospective from 2009 to 2012; and prospective from 2013 to 2015) was set up in a tertiary care hospital in Chandigarh, India, to enrol children <5 years of age admitted with intussusception as per Brighton's classification, to estimate the hospital admission rate. Incidence of intussusception among infants and children <5 years of age was also estimated.
Results:
A total of 277 intussusception cases (96 retrospective; 181 prospective) were reported. Majority of cases were males (69.7%) and infants (72%). Median age at diagnosis was 10 months (interquartile range 6-12 months). Nearly 62% cases were treated surgically and 33% radiologically. Incidence was estimated to be 20/100 000 infants, and 5/100 000 children <5 years of age per year, in Chandigarh.
Conclusion:
Intussusception surveillance system provided background hospital admission and incidence rate before rotavirus vaccine introduction in North India.