Cytotoxic dihydrobenzofuran neolignans from Mappianthus iodoies
Zhi-Hua Jiang1, Yan-Ping Liu2, Ze-Hao Huang3
1Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China; College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, PR China.
Abstract:
Three new dihydrobenzofuran neolignans, mappiodoinins A-C (1-3), together with nine known analogues (4 -12) were isolated from the stems and leaves of Mappianthus iodoies. Their structures with the absolute configurations were elucidated by extensive spectroscopic methods. This is the first time to find dihydrobenzofuran neolignans from the genus Mappianthus. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW-480 in vitro. Neolignans 1-12 showed significant cytotoxic effects against various human cancer cell lines with IC50 values ranging from 0.16 to 18.62 μM.
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