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Neurobehavioral effects of intrathecal somatostatinergic treatment in subhuman primates
R Leblanc1, S Gauthier, M Gauvin
1Department of Neurology and Neurosurgery, Allan Memorial Institute, McGill University, Montreal, Quebec, Canada.
Neurology
|December 1, 1988
Abstract:
We infused somatostatin and its long-acting analogue (SMS 201-995) into the intracranial subarachnoid space of eight monkeys. Chronic infusions of SMS 201-995 produced marked neurotoxic effects characterized by truncal ataxia, dysmetria, and severe bradykinesia, with normal level of consciousness. Subcutaneous injection of apomorphine, a dopaminergic agonist, promptly reversed these effects. Further studies are required before intrathecal somatostatin replacement therapy can be offered to patients with Alzheimer's disease.