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Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...

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Related Experiment Video

Updated: Feb 20, 2026

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

No rat poison for me

Tsuyoshi Kaneko¹, Sary F Aranki¹

¹Division of Cardiac Surgery, Brigham and Women's Hospital, Boston, Mass.

The Journal of Thoracic and Cardiovascular Surgery

|October 19, 2017

Summary

No abstract available in PubMed .

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