Related Experiment Video

Updated: Feb 20, 2026

Y-27632 Enriches the Yield of Human Melanocytes from Adult Skin Tissues
08:06

Y-27632 Enriches the Yield of Human Melanocytes from Adult Skin Tissues

Published on: July 8, 2020

6.1K

A novel stilbene-like compound that inhibits melanoma growth by regulating melanocyte differentiation and

Noah A Stueven1, Nicholas M Schlaeger1, Aaron P Monte2

  • 1Biology Department, University of Wisconsin-River Falls, River Falls, WI 54022, United States.

Toxicology and Applied Pharmacology
|October 19, 2017
PubMed

Insights

A novel stilbene-like compound, A11, effectively inhibits melanoma growth by reducing cell division and promoting melanocyte-like morphology. This compound targets multiple signaling pathways, offering a promising new therapeutic strategy for melanoma.

Area of Science:

  • Oncology
  • Dermatology
  • Molecular Biology

Background:

  • Melanoma therapy faces challenges including drug resistance, complex signaling pathways, and tumor heterogeneity.
  • Combinational therapies targeting multiple pathways are emerging as a promising approach.

Purpose of the Study:

  • To investigate the therapeutic potential of a novel stilbene-like compound, A11, against melanoma.
  • To elucidate the mechanism of action of A11 in melanoma cells.

Main Methods:

  • Inhibition of melanoma growth was assessed in zebrafish embryos and mouse melanoma cells.
  • Cellular effects, including mitosis, apoptosis, and signaling pathway activation (MAPK, Akt), were analyzed.
  • Gene expression of melanocyte differentiation markers (Pax3, MITF) was evaluated.

Main Results:

  • A11 significantly inhibited melanoma growth in both zebrafish and mouse models.
  • A11 reduced cell proliferation (mitosis) without inducing apoptosis.
  • A11 treatment activated MAPK and Akt signaling pathways and led to down-regulation of melanocyte differentiation genes.

Conclusions:

  • A11 demonstrates therapeutic potential as a novel melanoma treatment.
  • A11 inhibits melanoma by suppressing melanocyte differentiation and proliferation.
  • Targeting multiple signaling pathways with agents like A11 offers a promising strategy for melanoma therapy.
Keywords:
A11AktMAPKMelanocyte differentiationMelanomamitf

More Related Videos

Quantification of Hypopigmentation Activity In Vitro06:08

Quantification of Hypopigmentation Activity In Vitro

Published on: March 6, 2019

12.0K
Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

9.6K

Related Concept Videos

Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.8K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
6.1K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.3K
Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
4.1K
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K