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Splicing factors as regulators of miRNA biogenesis - links to human disease

Madara Ratnadiwakara1, Monika Mohenska1, Minna-Liisa Änkö1

  • 1Department of Anatomy and Developmental Biology, Monash University and Monash Biomedicine Discovery Institute, Development and Stem Cells Program, Melbourne, VIC, Australia.

Seminars in Cell & Developmental Biology
|October 19, 2017
PubMed

Insights

Splicing factors regulate microRNA (miRNA) biogenesis through various mechanisms. Understanding these links between splicing factors and miRNAs is crucial for human disease research.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression post-transcriptionally.
  • miRNA biogenesis involves complex processing steps with essential enzymes like Drosha/DGCR8 and Dicer.
  • Emerging evidence implicates RNA-binding proteins, including splicing factors, in miRNA biogenesis.

Purpose of the Study:

  • To review the mechanisms by which splicing factors regulate miRNA biogenesis.
  • To explore the implications of the interplay between splicing factors and miRNAs in human diseases.

Main Methods:

  • Literature review focusing on studies investigating splicing factor involvement in miRNA processing.
  • Analysis of mechanisms linking splicing factors to miRNA biogenesis pathways.
  • Discussion of the role of splicing factor-miRNA interactions in disease pathology.

Main Results:

  • Splicing factors have been identified as regulators of specific miRNA production.
  • These factors influence miRNA biogenesis through diverse molecular mechanisms.
  • The interaction between splicing factors and miRNAs is significant in the context of human diseases.

Conclusions:

  • Splicing factors play a critical role in modulating miRNA biogenesis.
  • The intricate relationship between splicing factors and miRNAs has profound implications for understanding and potentially treating human diseases.
Keywords:
RNA binding proteinSR proteinSplicing factorhnRNPmiRNA biogenesismiRNA processing

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