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Modeling of the homoeo domain suggests similar structure to repressors
P A Tsonis1, V Carperos, T Siahaan
1VA Medical Center, Indiana University, Indianapolis 46202.
Biochemical and Biophysical Research Communications
|November 30, 1988
Abstract:
The sequences of the homoeo domain containing the three alpha-helices were modeled based on secondary structure prediction, sequence homologies and coordinates of known helix-turn-helix motif containing DNA-binding proteins. The model reveals very similar three dimensional structure to repressors and suggest binding to DNA with its helix 3.