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Improving Palivizumab Compliance rough a Pharmacist-Managed RSV Prevention Clinic

Jennifer W Chow1, Michael F Chicella1, Anthony M Christensen1

  • 1Department of Pharmacy (JWC, MFC, JED), Children's Hospital of The King's Daughters, Norfolk, Virginia, Department of Pediatrics (MFC, CSM, JH), Eastern Virginia Medical School, Norfolk, Virginia, Department of Pharmaceutical Services (AMC), St. Jude Children's Research Hospital, Memphis, Tennessee.

The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG
|October 19, 2017
PubMed

Insights

A pharmacist-managed clinic significantly improved compliance with monthly palivizumab (RSV monoclonal antibody) dosing for high-risk infants. This approach enhances respiratory syncytial virus (RSV) prevention effectiveness.

Area of Science:

  • Pediatric Infectious Diseases
  • Pharmacology and Pharmaceutical Sciences

Background:

  • Palivizumab is a monoclonal antibody for preventing serious respiratory syncytial virus (RSV) infections in high-risk children.
  • Suboptimal adherence to monthly palivizumab dosing reduces its effectiveness.
  • A pharmacist-managed clinic was established to improve palivizumab compliance.

Purpose of the Study:

  • To evaluate the impact of a pharmacist-managed RSV prevention clinic on palivizumab dosing compliance.

Main Methods:

  • A retrospective chart review identified patients receiving palivizumab between September 2009 and April 2012.
  • Compliance was defined by the proportion of patients receiving eligible doses at 28- to 30-day intervals.

Main Results:

  • 172 patients received at least one dose of palivizumab.
  • An average of 92% of patients completed all scheduled doses during the RSV season.
  • 88% of patients received doses at the recommended 28- to 30-day intervals.

Conclusions:

  • A pharmacist-managed clinic effectively increases palivizumab dosing compliance.
  • This model supports physicians in RSV prevention strategies.
  • Improved compliance enhances the efficacy of palivizumab for pediatric RSV prevention.
Abstract

Keywords:
complianceinfantpalivizumabrespiratory syncytial viruses

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