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APV, an N-methyl-D-aspartate receptor antagonist, blocks the hippocampal theta rhythm in behaving rats
1Department of Clinical Neurological Sciences, University of Western Ontario, London, Canada.
Brain Research
|October 25, 1988
Abstract:
2-Aminophosphonovaleric acid (APV), an N-methyl-D-aspartate (NMDA) receptor antagonist, was infused into the lateral ventricles of behaving rats. A 10 or 20 microgram dose of APV attenuated the hippocampal theta rhythm and the theta phase-shift at the apical dendrites of hippocampal CA1 region. A selective suppression of the atropine-sensitive theta rhythm was suggested.