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Related Concept Videos

Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

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Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

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Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
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Barrett Esophagus-I: Introduction01:21

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Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
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Author Correction: Acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand management of acute disease.

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Related Experiment Video

Updated: Feb 20, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
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Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

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Recent advances in eosinophilic esophagitis.

Sandy Durrani1, Marc Rothenberg1

  • 1Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati OH, 45529, USA.

F1000Research
|October 19, 2017
PubMed
Summary

Eosinophilic esophagitis is a rising esophageal disease. Proton pump inhibitors (PPIs) are now first-line treatment, alongside corticosteroids and diet changes, though new research is needed.

Keywords:
Eosinophilic esophagitisProton-Pump inhibitorTopical Croticosteroid

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Area of Science:

  • Gastroenterology
  • Immunology
  • Genetics

Background:

  • Eosinophilic esophagitis (EoE) is a chronic, antigen-driven, eosinophil-predominant esophageal inflammatory disease affecting children and adults.
  • Genome-wide association studies have significantly advanced understanding of EoE pathogenesis.
  • Disease development involves a complex interplay of genetic/environmental factors, allergic sensitization, and esophageal pathways.

Purpose of the Study:

  • To review current understanding of eosinophilic esophagitis pathogenesis.
  • To discuss recent advances in diagnostic and therapeutic strategies.
  • To identify unmet needs in EoE research and clinical practice.

Main Methods:

  • Review of recent genetic and mechanistic studies.
  • Analysis of epidemiologic trends and treatment guidelines.
  • Synthesis of findings from systemic reviews and meta-analyses.

Main Results:

  • EoE incidence and prevalence are increasing globally.
  • Proton pump inhibitors (PPIs) are now recommended as first-line therapy, replacing the term 'PPI-responsive esophageal eosinophilia'.
  • PPIs, topical corticosteroids, and empiric food elimination diets are confirmed effective treatments.

Conclusions:

  • EoE is a growing public health concern requiring further research.
  • Updated guidelines recommend PPIs as a primary treatment modality.
  • Future research should focus on birth cohort studies, diagnostic tools, monitoring methods, and novel therapies.