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Published on: February 8, 2019
Crescentic glomerulonephritis with dual positive anti-GBM and C-ANCA/PR3 antibodies
Bolanle A Omotoso1,2, Helen P Cathro3, Rasheed A Balogun1
1Department of Internal Medicine, Division of Nephrology.
Abstract:
Antiglomerular basement membrane (anti-GBM) antibodies are more often accompanied by myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) than by proteinase 3 antineutrophil cytoplasmic antibody (PR3-ANCA). Both disease processes can affect the kidneys and/or the lungs. Patients with dual positive disease may have an atypical presentation which may delay diagnosis and treatment. Here we report a case of crescentic glomerulonephritis associated with positive PR3-ANCA and anti-GBM antibodies who underwent both lung and kidney biopsies.
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