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MicroRNA detection at femtomolar concentrations with isothermal amplification and a biological nanopore
Haolin Zhang1, Moe Hiratani, Kentaro Nagaoka
1Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.
Nanoscale
|October 19, 2017
Abstract:
One of the greatest challenges faced by chemists and biologists is the detection of molecules at extremely low concentrations. This paper describes a method to detect ultra-low concentrations (1 femtomole) of nucleotides using isothermal amplification and a biological nanopore.
