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Hypertension in Coarctation of the Aorta: Challenges in Diagnosis in Children
Trisha V Vigneswaran1,2, Manish D Sinha3, Israel Valverde1,2,4
1Department of Congenital Heart Disease, Evelina London Children's Hospital, Guy's & St Thomas' Hospitals, London, SE1 7EH, UK.
Insights
Children repaired for coarctation of the aorta (COA) often develop hypertension, increasing long-term cardiovascular risks. Early blood pressure monitoring and assessment are crucial for timely intervention in pediatric patients.
Area of Science:
- Cardiology
- Pediatric Cardiovascular Health
Background:
- Coarctation of the aorta (COA) repair in childhood does not eliminate long-term cardiovascular risks.
- Hypertension affects up to one-third of repaired COA patients, driving premature cardiovascular events.
- Existing cardiovascular surveillance pathways are defined for adults, not children post-COA repair.
Purpose of the Study:
- To review the prevalence and pathophysiology of hypertension in children after successful COA repair.
- To discuss challenges in pediatric blood pressure assessment and central blood pressure measurement.
- To highlight the need for enhanced cardiovascular surveillance strategies in pediatric COA patients.
Main Methods:
- Literature review focusing on hypertension post-COA repair in children.
- Discussion of blood pressure assessment challenges and non-invasive central blood pressure measures.
- Exploration of complementary cardiovascular assessment techniques for pediatric patients.
Main Results:
- Systolic arterial hypertension is a common complication in children post-COA repair.
- Accurate blood pressure assessment in this cohort presents significant challenges.
- Non-invasive central blood pressure monitoring offers potential for improved assessment.
Conclusions:
- Pediatric patients with repaired COA require dedicated cardiovascular surveillance.
- Timely identification and treatment of hypertension are essential to mitigate long-term risks.
- Further research into pediatric-specific assessment techniques is warranted.
Abstract:
Evidence indicates that patients with coarctation of the aorta (COA) suffer from increased cardiovascular morbidity and mortality in later life despite successful repair of COA in childhood. Systolic arterial hypertension is common, presenting in up to one-third of patients, and is regarded as the main driver of premature cardiovascular events in this group of patients. In this review, we discuss the prevalence and pathophysiology of hypertension in children following successful COA repair with no residual arch obstruction. The challenges in accurate blood pressure assessment at this early phase are considered and non-invasive measures of central blood pressure are discussed. Although the pathways for investigations in adults are well defined, we highlight the need to address the issues of cardiovascular surveillance in children and describe techniques which can provide complementary information for cardiovascular assessment in this group of patients such that timely treatment can occur.
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