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Renal involvement in paediatric systemic vasculitis.

Linnea Augestad, Clara Hammarström, Berit Flatø

    Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
    |October 19, 2017
    PubMed
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    Systemic vasculitis in children often affects kidneys, with over half showing renal involvement. Many children require ongoing treatment for kidney disease, highlighting the importance of early diagnosis and management.

    Area of Science:

    • Pediatric Nephrology
    • Rheumatology
    • Immunology

    Background:

    • Primary systemic vasculitis is a rare pediatric condition often presenting with subtle, progressive symptoms, leading to delayed diagnosis.
    • Early intervention is crucial to prevent severe kidney disease progression in affected children.

    Purpose of the Study:

    • To assess the prevalence and extent of renal involvement in children diagnosed with primary systemic vasculitis.
    • To evaluate the long-term renal outcomes and management strategies for pediatric patients with systemic vasculitis.

    Main Methods:

    • Retrospective observational study analyzing medical records, laboratory data, and renal biopsies.
    • Data collected from patients under 18 years old treated at Oslo University Hospital, Rikshospitalet, between 2000 and 2014.

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    Main Results:

    • 66 children with primary systemic vasculitis were identified; 59% had renal involvement at initial consultation, rising to 64% during the disease course.
    • 41 patients had confirmed renal involvement, with 12 requiring ongoing treatment for renal impairment, 3 undergoing transplantation, and 11 achieving medication-free remission.

    Conclusions:

    • Pediatric systemic vasculitis frequently involves the kidneys, necessitating vigilant monitoring and management.
    • A significant proportion of children with vasculitis-related kidney disease require long-term medical care and follow-up.