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Updated: Feb 20, 2026

On-Chip Octanol-Assisted Liposome Assembly for Bioengineering
Published on: March 17, 2023
Programmable fusion of liposomes mediated by lipidated PNA
A Rabe1, P M G Löffler, O Ries
1Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark. snv@sdu.dk.
Abstract:
We recently reported a DNA-programmed fusion cascade enabling the use of liposomes as nanoreactors for compartmentalized chemical reactions. This communication reports an alternative and robust strategy based on lipidated peptide nucleic acids (LiPs). LiPs enabled fusion of liposomes with remarkable 31% efficiency at 50 °C with low leakage (5%).
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