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High stability of gold nanoparticles towards DNA modification and efficient hybridization via a surfactant-free
Xin-Yi Li1, Fu-Yan Feng, Zi-Tong Wu
1Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China. zhouxd@whu.edu.cn jmhu@whu.edu.cn.
Chemical Communications (Cambridge, England)
|October 19, 2017
Abstract:
With the assistance of peptides, a stable and highly efficient approach for the quick loading of thiol-DNA onto AuNPs is proposed with a high DNA utilization, which is generally applicable to specific DNA detection and diverse AuNP sizes. The maximum efficiency of hybridization reached 93% while the reaction time was shortened to 30 min.
