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Related Experiment Videos

Rapid tranquilization: antipsychotics or benzodiazepines?

W R Dubin1

  • 1Philadelphia Psychiatric Center, PA 19131.

The Journal of Clinical Psychiatry
|December 1, 1988
PubMed
Summary
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Rapid tranquilization (RT) effectively manages agitated patients, but concerns about antipsychotic side effects are prompting research into alternatives like benzodiazepines. This review examines current literature and proposes guidelines for RT drug selection.

Area of Science:

  • Psychiatry
  • Emergency Medicine
  • Pharmacology

Background:

  • Rapid tranquilization (RT) is crucial in emergency psychiatry for managing agitated patients.
  • Antipsychotics are effective for RT but carry risks like neuroleptic malignant syndrome and extrapyramidal symptoms.
  • Concerns over side effects drive the search for alternative RT medications.

Purpose of the Study:

  • To review the literature on antipsychotics and benzodiazepines for rapid tranquilization.
  • To critically examine the use of benzodiazepines, specifically lorazepam and clonazepam, for RT.
  • To propose guidelines and future research directions for RT.

Main Methods:

  • Literature review of antipsychotics and benzodiazepines for rapid tranquilization.
  • Summary of findings from extensive RT reviews.

Related Experiment Videos

  • Critical analysis of benzodiazepine use in RT, focusing on lorazepam and clonazepam.

    • Main Results:

    • Antipsychotics are established for safe and effective RT.
    • Benzodiazepines are emerging as a viable alternative to antipsychotics for RT.
    • Lorazepam and clonazepam show promise in RT, warranting further investigation.

    Conclusions:

    • Benzodiazepines represent a significant alternative for rapid tranquilization.
    • Further research is needed to establish optimal benzodiazepine protocols for RT.
    • Tentative guidelines for RT drug selection are proposed based on current evidence.