Effect of nephrectomy for retroperitoneal sarcoma on post-operative renal function.

Area of Science:

• Oncology
• Nephrology
• Surgical Oncology

Background:

• Retroperitoneal sarcomas (RPS) often necessitate ipsilateral kidney removal during surgical resection.
• Assessing long-term renal function post-nephrectomy in RPS patients is crucial.

Purpose of the Study:

• To evaluate the long-term post-operative renal function in patients who underwent nephrectomy as part of an en-bloc resection for RPS.

Main Methods:

• Retrospective review of an institutional database (1990-2014).
• Included RPS patients who underwent nephrectomy for curative intent.
• Primary outcome: chronic kidney disease (CKD) staging based on glomerular filtration rate (GFR).

Main Results:

• 47 patients analyzed; 40% had preoperative CKD stage 1, 38% stage 2, 21% stage 3.
• Average GFR decrease of 33.4 mL/min/1.73 m² observed.
• 66% showed mild renal impairment progression; only 6% advanced to CKD stage 4 or 5.

Conclusions:

• Nephrectomy during RPS en-bloc resection leads to a GFR decrease that is not clinically significant.
• Surgeons should not withhold nephrectomy due to concerns about kidney failure in RPS treatment.