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Published on: November 20, 2015
Short- and long-term complications of in utero exposure to lamotrigine
Merav Cohen-Israel1, Itai Berger2, Einat Y Martonovich1,3
1Department of Pediatrics, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Aims:
The present study evaluates the effect of antenatal lamotrigine exposure, on short- and long-term paediatric outcome.
Methods:
The study included the children of 83 epileptic women treated with lamotrigine during pregnancy, at a tertiary medical centre between 2004-2014. All newborns were monitored for vital signs, congenital malformations and Finnegan score. In addition, the parents completed a questionnaire regarding their child's development and health up to the age of 12 years.
Results:
No major malformations were found in the newborns. None of the newborns had significant withdrawal symptoms by Finnegan score. The children were followed-up to the age of 12 years (56.6% were 6-12 years at the time of evaluation). There were no significant findings in the incidence of neurodevelopmental disorders.
Conclusions:
According to our experience, lamotrigine is generally safe for pregnancy use, associated with minimal short-term complications with no long-term effects on the outcome.
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