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MMP1 and MMP3 gene polymorphisms in patients with acute coronary syndromes

Andrzej Pawlik1, Marzenna Plucinska2, Mikołaj Kopec1

  • 1Department of Physiology, Pomeranian Medical University, Szczecin, Poland.

IUBMB Life
|October 19, 2017
PubMed

Insights

The MMP3-1171dupA gene variant (rs3025058) 6A/6A genotype is linked to a higher risk of acute coronary syndromes (ACS), specifically unstable angina. No significant association was found for the MMP1-1607dupG polymorphism.

Area of Science:

  • Cardiovascular Genetics
  • Molecular Biology
  • Biochemistry

Background:

  • Matrix metalloproteinases (MMPs) degrade connective tissue, contributing to unstable atherosclerotic plaques.
  • Genetic variations in MMPs may influence susceptibility to cardiovascular diseases like acute coronary syndromes (ACS).

Purpose of the Study:

  • To investigate the association between specific gene polymorphisms in MMP1 (rs1799750) and MMP3 (rs3025058) and the risk of ACS presenting as unstable angina.

Main Methods:

  • Case-control study involving 197 patients with unstable angina and 144 healthy controls.
  • Genotyping for MMP1-1607dupG (rs1799750) and MMP3-1171dupA (rs3025058) polymorphisms using coronary angiography for diagnosis.
  • Statistical analysis, including multivariate logistic regression, to determine associations.

Main Results:

  • No significant difference in MMP1-1607dupG (rs1799750) polymorphism distribution between patients and controls.
  • A significantly higher frequency of the MMP3-1171dupA (rs3025058) 6A/6A genotype was observed in unstable angina patients compared to controls.
  • Male sex and the rs3025058 6A/6A genotype were independently associated with an increased risk of ACS.

Conclusions:

  • The MMP3-1171dupA (rs3025058) 6A/6A genotype is a potential genetic risk factor for developing acute coronary syndromes (unstable angina).
  • MMP1 gene polymorphism (rs1799750) does not appear to be associated with unstable angina in this population.
Keywords:
MMP1MMP3acute coronary syndromesgene polymorphismsmetalloproteinases

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