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Updated: Feb 20, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
A simple validated multi-analyte method for detecting drugs in oral fluid by ultra-performance liquid
Yufang Zheng1, Erik Sparve1, Mats Bergström1
1Department of Laboratory Medicine, Department of Drug Abuse, Unilabs AB, Eskilstuna, Sweden.
Abstract:
A UPLC-MS/MS method was developed to identify and quantitate 37 commonly abused drugs in oral fluid. Drugs of interest included amphetamines, benzodiazepines, cocaine, opiates, opioids, phencyclidine and tetrahydrocannabinol. Sample preparation and extraction are simple, and analysis times short. Validation showed satisfactory performance at relevant concentrations. The possibility of contaminated samples as well as the interpretation in relation to well-knows matrices, such as urine, will demand further study.
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