Imaging Neoadjuvant Therapy Response in Breast Cancer
Amy M Fowler1, David A Mankoff1, Bonnie N Joe1
1From the Department of Radiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792-3252 (A.M.F.); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa (D.A.M.); and Department of Radiology and Biomedical Imaging, University of California-San Francisco School of Medicine, San Francisco, Calif (B.N.J.).
Neoadjuvant systemic therapy is increasingly used for breast cancer. This review discusses current and emerging imaging techniques to assess treatment response, complementing physical exams.
Area of Science:
- Oncology
- Radiology
- Medical Imaging
Background:
- Neoadjuvant systemic therapy use in breast cancer is expanding beyond locally advanced cases.
- Accurate assessment of treatment response is crucial for guiding therapy.
- Conventional methods like physical examination have limitations in evaluating response.
Purpose of the Study:
- To review current imaging modalities for assessing neoadjuvant therapy response in primary breast cancer.
- To discuss the advantages and limitations of existing assessment techniques.
- To explore emerging functional and molecular imaging approaches.
Main Methods:
- Review of current literature on breast cancer imaging and neoadjuvant therapy response assessment.
- Discussion of established imaging techniques (e.g., MRI, PET).
- Exploration of novel functional and molecular imaging strategies.
Main Results:
- Current imaging offers valuable insights into treatment response, supplementing clinical evaluation.
- Limitations exist in conventional methods for precise response assessment.
- Functional and molecular imaging show promise for more accurate and earlier response detection.
Conclusions:
- Imaging plays a vital role in monitoring neoadjuvant therapy for breast cancer patients.
- Emerging imaging techniques hold potential for improved evaluation of treatment efficacy.
- Further research is needed to validate advanced imaging methods in clinical practice.
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